.40 is known for being "snappy" or causing great muzzle flip. i can tame it on my firearm though. making reaquisition of target quicker.
But can you tame it shooting one handed firing off 3 shots per second as you use your offhand to deflect a knife while ducking a baseball bat from the other guy?
AS far as my opinion on Calibers. I am plenty happy carrying 9mm. But I can see a situation where my 9mm round just SLIGHTLY misses the heart where as a larger diameter bullet could put a slice into it. But the attacker can still be lethal even without a heart until the oxygen in your brain runs out. So it's MEH, carry whatever you are comfortable with. A .22 on the hip is better than a howitzer in your night stand.
...How awesome would that be.