Pretty sure most of the 'bad' comes from the so called 'war on drugs'. Prohibition has fueled the profits in the black markets, and flooded the streets with violence between competing suppliers, and products of widely varying potency and purity.
I'n not a user of currently illegal drugs, and not likely to become a user if they become legal, but I believe it's time we drag this travesty into the light of day- the best antiseptic. Too bad the trade props up 'allies' in South America; our government wouldn't want them to have to play by civilized rules.